Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndromeCOVID-19 감염 및 원발성 쇼그렌 증후군에 대한 잠재적인 일반적인 병원성 메커니즘의 생물정보학 분석Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] analysis Analysis CDCA2 cellular component cellular components CMPK2 COVID-19 COVID-19 infection cytoHubba database DEGs diagnostic Diagnostic markers differentially expressed differentially expressed gene Differentially expressed genes downloaded Evidence functional annotation Gene Expression Omnibus gene expression profile Gene expression profiles gene regulatory network General population Genes GEO HERC5 hub genes Ifi44 IFI44L IFIT1 IFIT2 IFIT3 marker mechanism metabolic pathway metabolic pathways molecular mechanism molecular mechanisms MX1 participated Pathogenesis pathogenic mechanism pathway Patient performed PPI Prevalence primary Sjogren’s syndrome. progression protein-protein interaction regulatory network reveal RRM2 selected significantly higher Sjögren’s syndrome subsequent analyses syndrome TOP2A transcription factor TYMS [DOI] 10.3389/fimmu.2022.938837 PMC 바로가기 [Article Type] Article
Identification of novel regulatory pathways across normal human bronchial epithelial cell lines (NHBEs) and peripheral blood mononuclear cell lines (PBMCs) in COVID-19 patients using transcriptome analysisResearch article Published on 2022-06-022022-10-05 Journal: Informatics in Medicine Unlocked [Category] 변종, 신약개발, [키워드] affected Analysis analysis approaches association cell line cell lines changes in conducted contribute Coronaviruses COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Differential gene expression Drug repurposing enrichment analysis epithelial epithelial cell line exacerbated Factor Gene regulatory networks help identification identify immune system Interaction interactions Lungs mononuclear cell Mutation neurodegenerative disorders NHBE organ pathway Pathway analysis PBMC PBMCs Peripheral blood regulatory network regulatory pathway SARS-CoV-2 significant pathway Streamline Support targets the disease the SARS-CoV-2 therapeutic approach Transcriptome viral replication viral strain virus [DOI] 10.1016/j.imu.2022.100979 [Article Type] Research article
Identification of Diagnostic Gene Markers and Immune Infiltration in Systemic Lupus전신성 루푸스에서 진단 유전자 마커 및 면역 침윤의 식별Article Published on 2022-05-102022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 바이오마커, 치료기술, [키워드] Activation advancement analysis Analysis analyzed Atypical autoantibodies autoantibody Autoantigens Autoimmune disease B cells bioinformatics Biomarker Central nervous system characteristic clinical manifestation clinical manifestations Clinical practice coexpressed coexpression network complexes control group coronavirus coronavirus disease correlation COVID-19 current DEGs determine Diagnosis diagnostic differentially expressed gene Differentially expressed genes disease downloaded downregulated Endocrine endocrine system enrichment analysis etiology evaluate expression data Factors fraction functional gene expression profile Genes Genetic GEO database healthy control healthy controls help heterogeneous highest hub genes human body identification identify Immune cell immune cells Immune complexes immune function Infection Interaction joints KEGG kidney leukemia Lupus lupus erythematosus miRNA multiple organs Participation Pathogenesis pathway Pathways Patient patients performed Population Potential biomarker potential biomarkers PPI PPI network protein-protein interaction receiver operating characteristic recognize regulatory network Research resulting ribosome ROC ROC Curve RPL19 RPS17 RPS19 RPS7 selected skin SLE SLE patient SLE patients Symptom systemic systemic lupus erythematosus T cell T cells the disease the healthy transcription factor Treatment turquoise module upregulated variety virus was selected was used weighted gene coexpression network analysis WGCNA whole blood sample [DOI] 10.1155/2022/3386999 PMC 바로가기 [Article Type] Article
The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune responseSARS-CoV-2 감염 동안 lncRNA, RNA 결합 단백질 및 바이러스 게놈 사이의 상호 작용은 RNA 대사 및 면역 반응과 관련된 조절 사건과의 강력한 연결을 보여줍니다Article Published on 2022-05-092022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] analyzed association BISPR Cell cellular cellular response characterized Cohort cohort of patient Combination complex component composed connection coronavirus Correlation analysis Defense defense mechanisms determine element event experimental evidence FMR1 FMR1-IT1 functional Host host cells human host cell human host cells human RNA identify immune response in silico infected cell Infection infectious agent Interaction interactions interferon interferon response intrinsic involved lncRNA long non-coding RNA mechanism metabolism MIR155HG modulate molecular ncRNAs Non-coding RNAs NRIR performed progression Protein rationale Regulation Regulatory regulatory network regulatory network. replicative reveal RNA RNA viruses RNA-binding protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load sequestering Specific Surveillance the interferon transcriptional transcriptomic triggered USP30 USP30-AS1 Viral viral genome viral infections viral RNA genome [DOI] 10.7150/thno.73268 PMC 바로가기 [Article Type] Article
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells Research Published on 2022-03-172022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acute SARS-CoV-2 infection Analysis Autoimmunity Cancer Cancer therapy expression feature Genes IFN-I IFN-I response Immunotherapy in vitro Infectious disease inhibiting interferon LAG-3 mechanism mRNA Perturbation receptor regulate regulatory network SP140 T cell T cells target TFS TIGIT transcription factor transcriptional Type type 1 interferon unique [DOI] 10.1038/s41590-022-01152-y [Article Type] Research
Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types슈퍼 대화식 프로모터는 혈액 계통 세포 유형에서 세포 유형-특이 적 조절 네트워크에 대한 통찰력을 제공Research Article Published on 2022-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis analysis ATAC-seq binding Blood blood cell Blood cells capture CD4 Cell cell type cell types chromatin compendium complex Critical disrupt driven by enhancer enhancers EPHB3 ETS1 explain Express expression level FIVE Follow-up functional Genetic variant GWAS GWAS variant GWAS variants help hematological hypothese identify implication include independent Interaction interactions interactivity Interpretation Lineage locus lymphocyte Lymphocyte count motifs norm overlap Phenotypes PIR Platelet Platelet count promoter promoters provide redundancy Region regions Regulatory regulatory network regulatory region resource strong interactions traits transcription factor transcriptional transcriptional regulation variant variants [DOI] 10.1371/journal.pgen.1009984 PMC 바로가기 [Article Type] Research Article
Identification of transcriptional regulatory network associated with response of host epithelial cells to SARS-CoV-2SARS-COV-2에 대한 숙주 상피 세포의 반응과 관련된 전사 조절 네트워크의 확인Article Published on 2021-12-142022-09-10 Journal: Scientific Reports [Category] SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] addition analyses approach BTK change Combination complications of COVID-19 Computational biology and bioinformatics computational tool contribute COVID-19 disease epithelial cell epithelial cells exacerbate Gene Expression Gene regulatory networks Host host cell host cells identification identify Immunity Infection Inflammation involved kinase kinases MAPK14 mechanism mitigate organ damage other respiratory virus Other respiratory viruses pathway Pathways provide reflect Regulation Regulatory regulatory network respiratory SARS-CoV-2 Signaling Systems biology therapeutic target transcriptional virus viruses [DOI] 10.1038/s41598-021-03309-5 PMC 바로가기 [Article Type] Article
Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study급성 폐 손상의 조절 및 COVID-19 및 종양 진행과의 연관성에 관여하는 핵심 유전자 : 생물 정보학 및 실험 연구Research Article Published on 2021-11-222022-09-10 Journal: PLoS ONE [Category] MERS, 유전자 메커니즘, 진단, [키워드] acute lung injury administration analysed anti-inflammatory agents Anti-inflammatory therapy association Atla bioinformatics Bioinformatics analysis cancers caused CCL2 changes in core correlation COVID-19 patient COVID-19 patients datasets DEGs Dexamethasone differentially expressed gene Differentially expressed genes down-regulation element expression functional annotation gene expression pattern gene expression patterns identify Ifi44 infectious involved LPS lung lung damage Lung inflammation lung inflammatory response Lung injury lung tissue marker mechanism mice Mmp8 molecular molecular markers molecular mechanism molecular mechanisms murine murine model neoplasia NODAL non-infectious overlap pathology Patient Plaur progression protein-protein interaction Ptx3 reconstruction Regulation regulatory network respiratory reversed RSAD2 Rtp4 Saa1 SARS-CoV-2 SARS-COV-2 infection SERPINE1 SOCS3 survival susceptible systemic inflammation text mining therapeutic target therapeutic targets Timp1 up-regulated were assessed whole-genome microarray with COVID-19 [DOI] 10.1371/journal.pone.0260450 PMC 바로가기 [Article Type] Research Article
Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in HumansArticle Published on 2021-11-112022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] alteration anti-viral activity approach Brain candidate coronavirus COVID-19 COVID-19 infection DCTN1 disorder dissect drug DYNC1H1 enrichment analysis Granule Health host response Human identify impair innate immune insight involved LMNA Lung disease Manifestations microRNA miRNAs Mortality network performed Protein protein-protein interaction protein–protein interaction Proteins regulatory network SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein Signaling stress granule stress granule proteins translation Treatment viral replication [DOI] 10.3390/pathogens10111459 PMC 바로가기 [Article Type] Article
Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19말초 혈액 세포의 단일 세포 전사체는 COVID-19의 심각성을 나타내고 설명합니다.Article Published on 2021-10-012022-09-11 Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘, [키워드] accumulated activities addition Blood CD8 Cell cell interaction cell interactions cellular cellular and molecular Characteristics conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical critical cases critical COVID-19 patients cytokine Cytokines cytotoxicity declined discrepancy disease severity effector T cell exhibited healthy donors heterogeneous immune Immune cell immune function immune functions immune response immune responses immune system infected patient Inflammatory cytokine Inflammatory cytokines moderate monocyte Monocytes mononuclear cell natural killer pathogenic mechanisms patients PBMCs Peripheral blood peripheral blood cell Peripheral blood mononuclear cells proliferative quantity reduced regulatory network severity severity of COVID-19 significantly single-cell RNA-seq single-cell RNA-seq. single-cell transcriptome single-cell transcriptomes stages T cells T/NK cell transcription factor transcriptional Transcriptome Treatment Variation variations weakened with COVID-19 [DOI] 10.1007/s11427-020-1880-y PMC 바로가기 [Article Type] Article